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This may be related to the mechanism of reactive oxygen species (ROS) production involving in NADPH oxidase activation (So and Thorens, 2010)

Figure 2 Selecting which of the most promising antigens should be included in the MenB vaccine required an approach informed by sequence analysis of individual surface expressed proteins to assess the extent of their variation within the natural population of meningococcal strains (associated with invasive disease and carriage) and by evaluation of the cross-bactericidal activity of antisera raised against each of the antigens